Biology / Bio 1577 · Atom · ~20 seconds

Whole-Genome versus Whole-Exome Sequencing

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Whole-genome sequencing determines an organism's entire DNA sequence, while whole-exome sequencing determines only its protein-coding exon regions.

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Whole-exome sequencing reads the exons a gene's mRNA is built from, per Bio 1275, skipping the introns and non-coding DNA whole-genome sequencing includes.

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Whole-exome sequencing covers a smaller genome fraction by design — not a lower-resolution read of the regions whole-genome sequencing covers.

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1575Next-Generation Sequencing's Parallel Structure

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