Biology / Bio 0518 · Atom · ~20 seconds
Induced Fit
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Induced fit describes an enzyme and substrate each shifting shape slightly as they bind, refining an earlier model that pictured a rigid, instantaneous lock-and-key fit.
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As hexokinase binds glucose, the enzyme's own shape adjusts around it, tightening the fit beyond what a static lock-and-key model would allow.
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Induced fit expands lock-and-key into a dynamic, mutual-adjustment view — it is not lock-and-key restated.