Biology / Bio 0887 · Procedure · 60–90 seconds
The Cyclin-Cdk Activation Cycle
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A cyclin-dependent kinase becomes fully active only after binding a cyclin and then being phosphorylated at a specific site, and that active complex is dismantled again once the cyclin it depends on is degraded.
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Cdk activity depends on two separate conditions holding at once, cyclin binding and site-specific phosphorylation — satisfying only one leaves the complex inactive.
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