Biology / Bio 0891 · Atom · ~20 seconds
p53 and the DNA-Damage Response
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p53 monitors genomic DNA for damage at the G1 checkpoint, halting the cycle and recruiting repair enzymes, or triggering apoptosis if damage cannot be repaired.
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Rising p53 levels trigger p21 production, which enforces the halt by inhibiting cyclin-Cdk complexes.
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A functional p53 protects the organism by killing a damaged cell outright when repair fails.