Biology / Bio 1571 · Atom · ~20 seconds
Shotgun Sequencing and Contigs
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Shotgun sequencing breaks many genome copies into random overlapping fragments, sequences each, and reassembles them into a contig by matching overlaps.
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Two fragments whose ends share an identical overlapping sequence can be joined into one longer contig.
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A contig is only as reliable as its overlaps — too few overlapping fragments in a region leaves a gap no contig can close.