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Biology  /  Bio 1937  ·  Atom · ~20 seconds

Combination Therapy Against a Fast-Mutating Virus

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Combining antiviral drugs that target different replication steps makes resistance to all of them far less likely.

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Drug classes exist against four replication steps; HIV therapy mixes drugs from two or three classes so resistance to all is unlikely.

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A single antiviral drug alone lets a fast-mutating RNA virus evolve resistance quickly — combination therapy slows that evolution.